Publications

  1. Chen, Z., Liu, X., Feng, X., Lyu, A. & Zhou, W.* A systematic pharmacological strategy-based to decode the synergistic mechanism of 7,4'-dihydroxyflavone in combination with vitamin D3 against asthma. J Ethnopharmacol. 2025; 344: 119513.

  2. He, J., Wong, L. Y., Chen, S., Zhang, S. J., Chen, W., Bai, J. X., Wang, L., Wang, X. Q., Li, S. M. A., Li, Q., Fu, X. Q. & Yu, Z.L.* Inhibition of the PI3K/AKT signaling pathway contributes to the anti-renal cell carcinoma effects of deoxyelephantopin. Biomed Pharmacother. 2025; 187: 118136.

  3. He, Y., Chen, Z., Yang, L., Qiao, S., Su, Z., Ding, F., Ding, F., Xin, F., Xiang, S., Lyu, A. & Li, F.* The supporting role of Schwann cells in perineural invasion of pancreatic ductal adenocarcinoma. Front Pharamacol. 2025; 16: 1540027.

  4. Ji, Y.,* Li, J., Ma, L., Wang, Z., Du, B., Kwan, H.Y., Bian, Z. & Chu, C.C. Development of immune-regulatory pseudo-protein-coated iron oxide nanoparticles for enhanced treatment of triple-negative breast tumor. Nanomaterials 2025;15(13): 1006.

  5. Lin, Y., Wu, H., Wang, J., He, W., Hou, J., Martin, V. T., Zhu, C., Chen, Y., Zhong, J., Yu, B., Lu, A., Guan, D., Qin, G. & Chen, W.* Nicotinamide adenine dinucleotide-Loaded lubricated hydrogel microspheres with a three-pronged approach alleviate age-related osteoarthritis. ACS Nano. 2025; 19(18): 17606-26.

  6. Liu, Y., Yang, J., Yu, F., Li, L., Zhao, N., Lu, C., Lu, A. & He, X.* Research advances in traditional Chinese medicine formulae and active components targeting lipid metabolism for hepatocellular carcinoma therapy.  Front Pharmacol. 2025; 16: 1528671.

  7. Qiu, F., Xie, D., Chen, H., Wang, Z., Huang, J., Cao, C., Liang, Y., Yang, X., He, D. Y., Fu, X., Lu, A. & Liang, C.* Generation of cytotoxic aptamers specifically targeting fibroblast-like synoviocytes by CSCT-SELEX for treatment of rheumatoid arthritis. Ann Rheum Dis. 2025; 84(5): 726-45.

  8. Que, Z., Qi, D., Yang, Y., Yao, W., Liu, J., Li, Y., Yu, Y., Wang, L., Li, F., Zhang, G., Wu, E. & Tian, J.* Regulating chemoresistance and cancer stemness: the CDH17-YAP pathway in distinct cellular states of lung cancer CTC clusters. Cell Mol Biol Lett. 2025; 30(1): 23.

  9. Su, T., Shi, Z.Q., Tan, J.C., Liu, L.S., Zhao, B.Q., Fan, X.Y., Wang, C.Y.,* Kwan, H.Y.* & Liu, Z.Q.* Casticin activates Rheb GTPase by binding to residue Trp141 and induces tumor senescence. Pharmacol Res.  2025; 218:107855.

  10. Su, X., Li, X., He, X., Zhou, S., Lyu, A.* & Cai, Z.* A biotin-free diet attenuates the incidence of collagen-induced arthritis and alleviates microbial dysbiosis. Food Func. 2025. 16(12): 4983-93.

  11. Wang, X.Q., Yu, X.F., Li, A.S.M., Han, R.X., Wang, L., Wu, J.Y., Wu, Y., He, J.J., Liu, B., Tsui, W.M.S., Lu, G.H., Mo, H., Fu, X.Q. & Yu, Z.L.* Parthenolide inhibits Hsp90α ATPase activity and overcomes acquired BRAF-inhibitor resistance in cutaneous melanoma. Phytomedicine. 2025; 146: 157151.

  12. Wu, Y., Wu, J.Y., Bai, J.X., Wang, X.Q., Li, A.S.M., Fan, X.Y., Han, R.X., Wang, L., Dou, X., Fu, X.-. & Yu, Z.L.* Macrophage and keratinocyte cell assays suggest that the supercritical CO2 extract of black soybean possesses anti-inflammatory and skin barrier-protective effects. Food Res Int. 2025; 218: 116824.

  13. Xiang, S., Yang, L., He, Y., Ding, F., Qiao, S., Su, Z., Chen, Z., Lu, A. & Li, F.* Alpha-1 antitrypsin as a regulatory protease inhibitor modulating inflammation and shaping the tumor microenvironment in cancer.  Cells 2025; 14(2): 88.

  14. Yu, L., Luo, X., Zhang, Z., Li, X., Tian, M., Qian, J. X., Yang, J., Deng, R., Bai, X., Lu, C., Lu, A.* & Liu, Y.* Reinforced immunotherapy of M1 macrophage-derived exosomes with CEL on TNBC via regulating macrophage functions. J Adv Res. 2025; S2090-1232(25)00554-5.

  1. Chen, Y., Yang, J., Wang, C., Wang, T., Zeng, Y., Li, X., Zuo, Y., Chen, H., Zhang, C., Cao, Y., Sun, C., Wang, M., Cao, X., Ge, X., Liu, Y., Zhang, G., Deng, Y., Peng, C., Lu, A.* & Lu, J.* Aptamer-functionalized triptolide with release controllability as a promising targeted therapy against triple-negative breast cancer. J Exp Clin Cancer Res. 2024; 43(1): 207.

  2. Fan, X., Li, B., Zhang, F., Liu, M., Kwan, H.Y.* Liu, Z.,* Su, T*. FGF19-activated hepatic stellate cells release ANGPTL4 that promotes colorectal cancer liver metastasis. Adv Sci. 2024; 24:e2413525.

  3. Ma, Y., Xie, D., Chen, Z., Shen, X., Wu, X., Ding, F., Ding, S., Pan, Y., Li, F., Lu, A.* & Zhang, G.* Advancing targeted combination chemotherapy in triple negative breast cancer: Nucleolin aptamer-mediated controlled drug release. J Transl Med. 2024l 22(1): 604.

  4. Shi, Z., Zeng, H., Zhao, B., Zeng, C., Zhang, F., Liu, Z., Kwan, H.Y.,* Su, T.* Sulforaphane reverses the enhanced NSCLC metastasis by regulating the miR-7-5p/c-Myc/LDHA axis in the acidic tumor microenvironment. Phytomedicine 2024 Jul 16;133:155874.

  5. Wang, X., Xue, X., Pang, M., Yu, L., Qian, J., Li, X., Tian, M., Lyu, A., Lu, C. & Liu, Y.* Epithelial–mesenchymal plasticity in cancer: Signaling pathways and therapeutic targets. MedComm. 2024; 5(8): e659.

  6. Wu, Y., Dai, S., Zhang, Y. J., Li, Z., Zhu, B., Liu, Q., Wo, L., Yu, Z., Yuan, X. & Dou, X.* Atractylenolide II combined with Interferon-γ synergistically ameliorates colorectal cancer progression in vivo and in vitro by blocking the NF-kB p65/PD-L1 pathway. J Cancer 2024; 15(13): 4328-44.

  7. Xu, K., Fu, A., Li, Z., Miao, L., Lou, Z., Jiang, K., Lau, C., Su, T., Tong, T., Bao, J.,* Lyu, A.,* Kwan, H.Y.* Elevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions. Nat Commun. 2024; 15(1):1685.

  1. Du, Y.X., Mamun, A.A,. Lyu, A.P.,* Zhang, H.J.* Natural compounds targeting the autophagy pathway in the treatment of colorectal cancer. Int J Mol Sci. 2023; 24(8): 7310.

  2. Fan, X., Meng, M., Li, B., Chen, H., Tan, J., Xu, K., Xiao, S., Kwan, H.Y.,* Liu, Z.,* Su, T*. Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay. J Transl Med. 2023;21(1):260.

  3. Wang, X., Song, Y., Yu, L., Xue, X., Pang, M., Li, Y., Luo, X., Hua, Z., Lu, C., Lu, A.* & Liu, Y.* Co-delivery of hesperetin and cisplatin via hyaluronic acid-modified liposome for targeted inhibition of aggression and metastasis of triple-negative breast cancer. ACS Appl Mater Interfaces 2023; 15(29): 34360-77.

  4. Zhang, T., Han, X., Zhong, Y., Kam, H. T., Qiao, D., Chen, Z., Chan, K. W. Y., Chong, W. P.* & Chen, J.* Regulatory T cell intravitreal delivery using hyaluronan methylcellulose hydrogel improves therapeutic efficacy in experimental autoimmune uveitis. Biomater Adv. 2023; 151: 213496.

  5. Zhou, C., Yu, T., Zhu, R., Lu, J., Ouyang, X., Zhang, Z., Chen, Q., Li, J., Cui, J., Jiang, F., Jin, K. Y., Sarapultsev, A., Li, F., Zhang, G., Luo, S. & Hu, D.* Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation. Int J Biol Sci. 2023; 19(5): 1471-89.

  1. Gong, R.H., Chen, M., Huang, C., Wong, H.L.X., Kwan, H.Y.,* Bian, Z.* Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin-proteasome pathway. Cell Commun Signal 2022;20(1):34.

  2. Lu, J., Shuai, B., Shou, Z., Guo, W., Zhou, C., Ouyang, X., Zhou, H., Li, J., Cui, J., Jiang, F., Jin, K. Y., Sarapultsev, A., Li, F., Zhang, G., Luo, S. & Hu, D.* Taraxasterol inhibits tumor growth by inducing apoptosis and modulating the tumor microenvironment in non-small cell lung cancer. Cancers 2022; 14(19): 4645.

  3. Mamun, A.A., Uddin, M.S., Perveen, A., Jha, N.K., Alghamdi, B.S., Jeandet, P., Zhang, H.J., Ashraf, G.M.* Inflammation-targeted nanomedicine against brain cancer: From design strategies to future developments.Semin Cancer Biol. 2022; 86:101-16.

  4. Yu, X., Song, X., Zhang, Y., Yang, Y.M., Ye, J.H., Liu, Y.H., Pan, L.T.* & Zhang, H.J.* Design, synthesis and biological evaluation of lophanic acid derivatives as antifungal and antibacterial agents. Molecules 2022; 27(20): 6836.