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教學科研部副教授

中藥藥劑和藥物遞送系統制劑處方專家

yzhijun@hkbu.edu.hk

楊智鈞博士1986年畢業於沈陽藥科大學,同年起歷任中國藥科大學中藥制劑學助教和講師,期間曾在南京中醫藥大學學習中醫藥理論,也曾任日本岐阜藥科大學客座制劑研究員。楊博士於1993年留學日本千葉大學,1997年獲得藥劑學博士學位並受聘為日本大洋藥品工業株式會社[2011年更名テバ製薬株式會社(Teva Pharma Japan Inc.)]制劑研究員,2000年於加拿大University of British Columbia從事博士後研究,2001年任加拿大Northern Lipids Inc.脂質體處方開發科學家。





楊博士多年來研究中西藥藥劑理論,發表論文多篇,並集中開發了中西藥藥劑產品,其中十多個產品銷售於醫藥市場。楊博士現在的研究集中在中西藥藥劑學研究開發前沿,結合中醫藥理論和西藥藥物遞送系統理論,開發中西藥藥劑新產品,努力尋找制劑新方法和新理論。



資助項目


項目 1

Title: Immunoliposome delivery triptolide to lung cancer   enhanced by Carbonic Anhydrase IX Antibody 

Principal Investigator: Dr. Zhijun Yang (Ph.D.)

Funding Body: Hong Kong General Research Fund

Project ID: HKBU 12102514 

Exercise Year: 2015/2017

Approved Project Duration: 24 months 

Project Fund: HK$ 900,000 

Coordinator: ZhijuYang (Ph.D.)



項目 2

Title: BFGC300 and BFGT 600 mg

Principal Investigator: Dr. Zhijun Yang (Ph.D.) 

Funding Body: Bright Future Pharmaceutical Laboratories

Project ID: HKBU BFPLL/13-14/01 

Exercise Year: 2014/2016 

Approved Project Duration: 24 months 

Project Fund: Confidential 

Coordinator: ZhijuYang (Ph.D.)



項目 3

Title: Develop an emulsion-based formulation/nano-particle based formulation for Doxorubicin and Docetaxel

Principal Investigator: Dr. Zhijun Yang (Ph.D.) 

Funding Body: Kinex Pharmaceuticals 

Project ID: HKBU KP/13-14-01 

Exercise Year: 2014/2015

Approved Project Duration: 8 months 

Project Fund: confidential

Coordinator: ZhijuYang (Ph.D.)



 



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  黃慧琳博士


     ◆ 博士後
     ◆ 專業:生物化學和生理學
     ◆ 郵件:
hueilengng@yahoo.com 






1419913082111904.jpg

  


  張家勇


     ◆ 研究助理
     ◆ 專業:化學
     ◆ 郵件:
zhangjiayong-12@163.com








jiaho.jpg

 

  李嘉豪


     ◆ 研究助理

     ◆ 專業:中藥藥劑學、中藥藥理學

     ◆ 郵件:13433504@life.hkbu.edu.hk














1.      

Blenda Chi Kwan Wong, Hongqi Zhang, Ling Qin, Hubiao Chen, Chen Fang, Aiping Lu*Zhijun Yang*. Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro. Drug Design Development and Therapy. (in press)

2.      

Lin Wang, Ai-Ping Lu, Zhi-Ling Yu, Ricky N. S. Wong, ZhaoXiang Bian, HoiHin Kwok, Patrick YingKit Yue, LiMin Zhou, HuBiao Chen, Min Xu, Zhijun Yang*. The Melanogenesis-Inhibitory Effect and the Percutaneous Formulation of Ginsenoside Rb1. AAPS PharmSciTech (2014) DOI: 10.1208/s12249-014-0138-3

3.          

Tao Yi, Lin Zhu, Yi-Na Tang, Jian-Ye Zhang, Zhi-Tao Liang, Jun Xu, Zhong-Zhen Zhao, Zhi-Ling Yu, Zhao-Xiang Bian, Zhijun Yang, Hu-Biao Chen*. An integrated strategy based on UPLC–DAD–QTOF-MS for metabolism and pharmacokinetic studies of herbal medicines: Tibetan “Snow Lotus” herb (Saussurea laniceps), a case study. Journal of Ethnopharmacology 153 (2014) 701–713

4.      

Ting TingXiao, Min   Xu, XiaoHong Yang, Lam Kok, Yeuk Lung Chow, Zhong ZhenZhao, Kelvin Sze-Yin   Leung, Zhijun Yang, XiaoYing Tian, Zhi Li, Meng Yun Xin, Wei Xu. The evaluation on embryotoxicity of Dipsaci Radix with mice and embryonic stem cells. Journal of Ethnopharmacology 151 (2014) 114–122

5.    

Baosheng Guo, Baoting Zhang, Lizhen Zheng, Tao Tang, Jin Liu, Heng Wu, Zhijun Yang, Songlin Peng, Xiaojuan He, Hongqi Zhang, Kevin K.M. Yue, Fuchu He, Lingqiang Zhang, Ling Qin, Zhaoxiang Bian, Weihong Tan, Zicai Liang, Aiping Lu*, Ge Zhang*. Therapeutic RNAi targeting CKIP-1 with cross-species sequence to stimulate bone. Bone, 59 (Feb.2014), 76–88 15; doi:10.1016/j.bone. 2013.,.

6.          

Yang Zhijun*, Aiping Lu, Blenda Chi Kwan Wong, Xiaoyu Chen, Zhaoxiang Bian, Zhongzhen Zhao, Wenhua   Huang, Ge Zhang, Hubiao Chen, Min Xu. Effect of liposomes on the absorption   of water-soluble active pharmaceutical ingredients via oral administration. Current Pharmaceutical Design 2013; 19 (37): 6647-54. PMID: 23621538   2013 Apr 23. [Epub ahead of print] [PubMed-as supplied by publisher].

7.    

Zhang M, Zang KH, Luo JL, Leung FP, Huang Y, Lin CY, Yang Zhijun, Lu AP, Tang XD, Xu HX, Sung JJ, Bian ZX. Magnolol inhibits colonic   motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in rats. Phytomedicine. 2013 Aug 21. doi:pii: S0944-7113(13)00271-7.10.1016/j.phymed. 2013.07.008. [Epub ahead of print]; PMID:   23972358

8.    

Xiao HT, Tsang SW, Qin HY, Choi FF, Yang ZJ, Han QB, Chen HB, Xu HX, Shen H, Lu AP, Bian ZX. A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn. J Ethnopharmacol. 2013 Sep 16;149(2):499-505. doi: 10.1016/j.jep. 2013.07.007. Epub 2013 Jul 26. PMID: 23895917

9.        

Xiaogang Wang,   Baosheng Guo, Qi Li, Jiang Peng, Yang Zhijun, Aiyuan Wang,   Dong Li, Zhibo Hou, Ke Lv, Guanghan Kan, Heng Wu, Jinping Song, Xiaohua Pan,   Qiao Sun, Shukuan Ling, Yuheng Li, Mu Zhu, Pengfei Zhang, Songlin Peng, Xiaoqing Xie, An Hong, Ling Qin, Leungkim Hung, Yinghui Li, Zhaoxiang Bian, Yanqiang Bai, Aiping Lu, Shanguang Chen, Fuchu He, Ge Zhang*, Yingxian Li*.   miR-214 targets ATF4 to inhibit bone formation. Nature Medicine. 19(1) 93-100 (JANUARY 2013)

      10.

Xiaoyu Chen, Wenhua Huang, Blenda Chi Kwan Wong, Linlin Yin, Yuen Fan Wong, Min Xu, Yang Zhijun*. Liposomes prolong the therapeutic effect of   anti-asthmatic medication via pulmonary delivery. International Journal of Nanomedicine. 2012; 7:1139-1148.

      11.

Zhu GY, Wong BC, Lu A, Bian ZX, Zhang G, Chen HB, Wong YF, Fong WF*, Yang Zhijun*. Alkylphenols from the Roots of Ardisia brevicaulis Induce G1 Arrest and Apoptosis through Endoplasmic Reticulum Stress Pathway in Human Non-small-cell Lung Cancer Cells. Chem Pharm Bull. 2012; 60(8):1029-36.

12.   

Min Xu*, Xiao Ying Tian, Kelvin Sze-Yin   Leung, Kam Cheong Lee, Tak Chong Chow, Bin Deng, Chi Ming Yiu, Chi I Chow, Zhong Zhen Zhao, Yang Zhijun, Fong Wang Fun, Ting Ting Xiao, Wei Xu,   and Ping Xiang Deng. Embryotoxicity of Psoralea corylifolia L.: in vivo and   in vitro studies. Birth Defects   Research Part B: Developmental and Reproductive Toxicology. 2012; 95:386–394; DOI: 10.1002/bdrb.21028.

13.     

Ge Zhang*, Baosheng Guo, Heng Wu, Tao Tang, Baoting Zhang, Lizhen Zheng, Yixin   He, Yang Zhijun, Xiaohua Pan, Heelum Chow, Kinwah To, Yaping Li, Dahu Li, Xinluan Wang, Yixiang Wang, Kwongman Lee, Zhibo Hou, Nan Dong, Gang Li, Kwoksui Leung, Leungkim Hung, Fuchu He, Lingqiang Zhang*, Ling Qin*. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine. 2012; 18(2): 307-314.

14.   

He Yi-Xin, Liu Zhong, Pan Xiao-Hua, Tang Tao,   Guo Bao-Sheng, Zhen Li-zhen, Xie Xin-Hui, Wang Xin-Luan, Lee Kwong-Man, Li Gang, Cao Yong-Ping, Wei Lei, Chen Yang, Yang Zhijun, Hung Leung-Kim, Qin Ling, Zhang Ge*. Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model. Osteoporosis International. 2012, 23:377–389 (DOI10.1007/s00198-011-1812-x).

15.   

Hiu-Yee Kwan, Yang Zhijun, Wang-Fun Fong, Yong-Mei Hu, Zhi-Ling Yu, Wen-Luan Wendy Hsiao*. The anticancer effect of oridonin is mediated by fatty acid   synthase suppression in human colorectal cancer cells, Journal of Gastroenterology. 2012, DOI10.1007/s00535- 012-0612-1.

16.   

Hiu Yee Kwan, Wang Fun Fong, Zhijun Yang, Zhi-Ling Yu* , Wen-Luan Wendy Hsiao*. Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells. European Journal of Nutrition. 2012. DOI 10.1007/s00394- 012- 0467-5.

17.     

Tao Yi, Hongwing Lo, Zhongzhen Zhao, Zhiling Yu, Yang Zhijun and Hubiao Chen*. Comparison of the Chemical Composition and Pharmacological Effects of the   Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (Saussurea   laniceps) Herb. Molecules. 17, 7183-7194;   doi:10.3390/molecules17067183. 2012.

18.   

Hong-Yan Qin, Hai-Tao Xiao, Fung-Ping Leung, Yang Zhijun, Justin C. Y. Wu, Joseph J. Y. Sung, Hong-Xi Xu, Xu-Dong Tong, and Zhao-Xiang Bian*. JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell   Hyperplasia and Serotonin Availability in Rats. Evidence-Based Complementary and Alternative Medicine. 2012, Article ID 239638, 12 pages doi:10.1155/2012/239638.

19.   

Tao Yi, Yina Tang, Jianye Zhang, Zhongzhen Zhao, Yang Zhijun, Hubiao Chen*. Characterization and determination of six flavonoids in the ethnomedicine "Dragon's Blood" by UPLC-PAD-MS. Chemistry Central Journal. 2012; 6:116.

20.   

Shufang Nie, Wendy W L Hsiao, Weisan Pan, Yang Zhijun*. Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug   release, cell cytotoxicity and uptake studies. International Journal of Nanomedicin. 2011; 6: 151-166.

21.   

Xiao Ying Tian, Min Xu*, Bin Deng, Kelvin Sze-Yin Leung, King Fai Cheng, Zhong Zhen Zhao, Shi Ping Zhang, Yang Zhijun, Ping Xiang Deng, Dong Ying Xu, Xiao Ping Xu, Irene Koo, Michael Wong. The effects of Boehmeria nivea (L.) Gaud. on embryonic development: in vivo and in vitro studies. Journal of Ethnopharmacology. 2011;   134: 393–398.

22.   

Wenhua Huang, Yang Zhijun*, Heng Wu,Yuenfan Wong, Zhongzhen Zhao, Liang Liu. Development of liposomal salbutamol dry powder inhaler formulation. Biological & Pharmaceutical Bulletin. 2010; 33(3): 512-517.

23.   

Lin ZX*, Jiao BW, Che CT, Zuo Z, Mok CF, Zhao M, Ho WKK, Tse WP, Lam KY, Fan RQ, Yang Zhijun, Cheng CHK. Ethyl acetate fraction of the root of Rubia cordifolia L. inhibits keratinocyte proliferation in vitro and promotes keratinocyte differentiation in vivo: potential application for psoriasis treatment. Phytotherapy Research. 2010; 24(7): 1056-1064.

24.     

Yang Zhijun*, David Fong, Linlin Yin, Yuenfan Wong, Wenhua Huang. Liposomes modulate docetaxel-induced lipid oxidization and membrane damage in human hepatoma cells. Journal of Liposome Research. 2009; 19(2): 122-130.

25.   

趙中振*(監修)、陳虎彪(監修)楊智鈞(監訳)中薬材鑑定図典、生薬の中国伝統評価技法、株式会社エヌティーエス、2012、東京

26.     

杨智钧*:中药透皮吸收制剂的设计与方法,侯世祥*主编, 现代中药制剂设计理论与实践pp.633-649, 人民卫生出版社,2010,北京


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