Project 2

Title: Toward an emerging paradigm of network  medicine: An innovative platform to combinational herbs /

          compounds-based drug discovery for  complex diseases

Principal Investigator: Prof. Aiping  Lu (M.D., Ph.D.)

Funding Body: Interdisciplinary  Research Matching Scheme (IRMS) of Hong Kong Baptist University

Project ID: RC-IRMS/12-13/02

Exercise Year: 2012/2013

Approved Project Duration: 24 months

Project Fund: HK$ 3,000,000

Coordinator: Dr. Guang  Zheng (Ph.D.)

Project 3

Title: Skeletal role of CK2-interating  Protein-1 in Regulating Osteoblastic Bone Formation: Molecular

          Mechanism and Reversing Osteoporosis

Principal Investigator: Dr. Ge Zhang  (M.D.)

Funding Body: Research  Grants Council & Natural Science Foundation Council

Project ID: N_HKBU435/12

Exercise Year: 2012/2013

Approved Project Duration: 48 months

Project Fund: HK$ 753,925

Coordinator: Dr. Baosheng  Guo (Ph.D.)

Project 4

Title: Study on molecular mechanism of bone  formation reduction in aged women: Functional role of

         CKIP-1

Principal Investigator: Dr. Ge Zhang  (M.D.)

Funding Body: Natural  Science Foundation Council

Project ID: NSFC 81272045

Exercise Year: 2012/2013

Approved Project Duration: 36 months

Project Fund: RMB 700,000

Coordinator: Dr. Baosheng  Guo (Ph.D.)

Project 5

Title: Toward a novel bone anabolic strategy  for aged postmenopausal osteoporosis: Inhibiting miR-214

          inosteogenic cells for promoting bone  formation

Principal Investigator: Dr. Ge Zhang  (M.D.)

Funding Body: Hong Kong  General Research Fund

Project ID: HKBU 478312

Exercise Year: 2012/2013

Approved Project Duration: 30 months

Project Fund: HK$ 950,000

Coordinator: Dr. Baosheng  Guo  (Ph.D.)

Project 6

Title: Development of aptamer-conjugated  Triptolide specifically targeting synovial cell

Principal Investigator: Dr. Ge Zhang  (M.D.)

Funding Body: Institute of  Basic Research in Clinical Medicine, China Academy of Chinese

                         Medical Sciences (Contract Study)

Project ID: SCM-2012-CR-001

Exercise Year: 2012/2013

Approved Project Duration: N/A

Project Fund: RMB 500,000

Coordinator: Ms. Lei Dang  (B.Sc.)

Project 7

Title: Screening on anti-rheumatic herbal  medicines

Principal Investigator: Dr. Aiping Lu (M.D., Ph.D.)

Funding Body: Hong Kong Baptist University

Project ID: 33-12-903

Exercise Year: 2012/2013

Approved Project Duration: 24 months

Project Fund: HK$ 1,000,000

Coordinator: Dr. Cheng Lu (Ph.D.)

Project 8

Title: Does aberrantly overexpressed casein  kinase-2 interacting protein-1 contribute to failure

         of osteoblast-mediated repair for bone  erosion in rheumatoid arthritis?

Principal Investigator: Dr. Aiping Lu  (M.D., Ph.D.)

Funding Body: Kunshan RNAi  Institute (Contract Study)

Project ID: N/A

Exercise Year: 2013/2014

Approved Project Duration: 36 months

Project Fund: RMB 3,000,000

Coordinator: Dr. Xiaojuan  He (M.D.)

Project 9

Title: Understanding the molecular mechanism  in failure of osteoblast-mediated repair for articular

          bone erosion during progressive rheumatoid  arthritis: Role of casein kinase-2 interacting protein-1

          in controlling osteoblast function

Principal Investigator: Prof. Aiping  Lu (M.D., Ph.D.)

Funding Body: Research  Grants Council

Project ID: HKBU 261113

Exercise Year: 2013/2014

Approved Project Duration: 24 months

Project Fund: HK$ 606,223

Coordinator: Dr. Xiaojuan  He (M.D.)

Project 10

Title: Aptamer-functionalized  Osteoblast-targeting Delivery System for Osteogenic siRNAs to

         Achieve Cell-specific RNA interference  for Bone Anabolic Therapy

Principal Investigator: Dr. Ge Zhang  (M.D.)

Funding Body: Research  Committee of Hong Kong Baptist University

Project ID: FRG2/12-13/027

Exercise Year: 2013/2014

Approved Project Duration: 24 months

Project Fund: HK$ 135,000

Coordinator: Mr. Chao Liang  (M.S.)

Project 11

Title: Metabolomics Analysis of Chinese  Medicine in Epidemic Encephalitis B prevention and

          treatment

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Institute of Basic Research in Clinical Medicine, China Academy of  Chinese

                         Medical  Sciences (Contract Study)

Project ID: SCM-2013-CR-001

Exercise Year: 2013~

Approved Project Duration: N/A

Project Fund: RMB 500,000

Coordinator: Ms. Lei Dang (B.S.)

Project 12

Title: Establishing the bridge for  translating cell-specific RNA interference to bone anabolic therapy:

         An aptamer-functionalized  osteoblast-targeting delivery system for osteogenic siRNAs

Principal Investigator: Dr. Ge Zhang  (M.D.)

Funding Body: Science and Technology  Innovation Commission of Shenzhen Municipality

Project ID: SCM-2013-SZTIC-001

Exercise Year: 2013/2014

Approved Project Duration: 24 months

Project Fund: RMB 300,000

Coordinator: Mr. Chao Liang  (M.S.)

Project 13

Title: Research and development of  triptolide-aptamer drug

Principal Investigator: Prof. AipingLu  (M.D., Ph.D.)

Funding Body: National  Science and Technology Major Projects for "major New Drugs Innovation and

                         Development"

Project ID: 2013ZX09301307

Exercise Year: 2013/2015

Approved Project Duration: 36 months

Project Fund: RMB 1,500,000

Coordinator: Dr. Xiaojuan  He (M.D.)

Project 14

Title: A unique platform for drug discovery  of combinational drugs / Chinese herbal medicines / compounds

Principal Investigator: Prof. Aiping  Lu (M.D., Ph.D.)

Funding Body: Hong Kong Baptist University  Strategic Development Fund

Project ID: SDF13-1209-P01

Exercise Year: 2014/2017

Approved Project Duration: 36 months

Project Fund: HK$ 3,000,000

Coordinator: Dr. Guang  Zheng (Ph.D.)

Project 15

Title: Role of MiR-214 within Osteoclast in  Regulating Osteoblastic Bone Formation

Principal Investigator: Dr. Ge Zhang  (M.D.)

Funding Body: Research  Committee of Hong Kong Baptist University

Project ID: FRG2/13-14/006

Exercise Year: 2014/2016

Approved Project Duration: 24 months

Project Fund: HK$ 135,000

Coordinator: Dr. Defang  Li (Ph.D.)

Project 16

Title: The  Development of Chinese Medicine Clinical Practice Guidelines in Hong Kong

Principal Investigator: Prof. Aiping  LU (M.D., Ph.D.) & Prof. Zhaoxiang BIAN (M.D., Ph.D.)

Funding Body: Hospital  Authority

Project ID: HA 820/126/19/19/14/6/12/1

Exercise Year: 2013/2014

Approved Project Duration: 15 months

Project Fund: HK$ 444,320

Coordinator: Ms. Nannan Shi  (M.Phil.)

Project 17

Title: Cell-specific Aptamer Facilitates Triptolide Selectively Targeting Fibroblast-like Synoviocytes and Specifically

Reducing Exposure to Liver Cells

Principal  Investigator: Prof. Aiping LU (M.D., Ph.D.)

Funding Body: Research  Committee of Hong Kong Baptist University

Project  ID:  30-12-286

Exercise Year: 2013/2014

Approved Project  Duration: 18 months

Project Fund: HK$ 131,100

Coordinator: Dr. Cheng Lu (Ph.D.)

Project 18

Title: Role of  miR-214 from Osteoclast in Regulating Osteoblastic Bone Formation

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong  Baptist University

Project ID: RC-IRMS/13-14/02

Exercise Year: 2014/2015

Approved Project Duration: 24 months

Project Fund: HK$ 2,981,576

Coordinator: Dr. Defang  Li (Ph.D.)

Project 19

Title: Aptamer-functionalized  osteoblast-targeting delivery system for osteogenic siRNAs to achieve

cell-specific  RNA interference for bone anabolic therapy

Principal  Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Hong Kong  General Research Fund (GRF)

Project  ID:  12102914

Exercise Year: 2014/2015

Approved Project  Duration: 36 months

Project Fund: HK$ 1,035,000

Coordinator: Mr. Chao Liang  (M.S.)

Project 20

Title: Characterization  of Linkage between Symbiotic Gut Microbes and Fatty Acid Metabolism in

Rheumatoid Arthritis Patients

Principal Investigator: Prof. Aiping LU (M.D., Ph.D.) & Prof. Cai  Zongwei  (Ph.D.)

Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong  Baptist University

Project ID: RC-IRMS/13-14/03

Exercise Year: 2014/2015

Approved Project Duration: 24 months

Project Fund: HK$ 2,944,160

Coordinator: Dr. Cheng Lv  (Ph.D.)

Project 21

Title: Toward Targeted Therapy In Advanced  Pancreatic Cancer: A Smart Triptolide-Nucleolin Aptamer

         Conjugate (UIM/256)

Principal  Investigator: Prof. Aiping  Lu

Funding Body: Hong Kong  Innovation and Technology Fund

Project  ID:  UIM/256

Exercise Year: 2014/2016

Approved Project  Duration: 24 months

Project Fund: HK$ 2,339,560

Coordinator: Mr. Biao Liu  (M.S.)

Project 22

Title:Toward Cell-targeted Therapeutics in Osteosarcoma: a Smart Triptolide-aptamer Conjugate

Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) and Prof. Dean Guo (Ph.D.)

Funding Body: Croucher Foundation

Project ID: Gnt#CAS14BU/CAS14201

Exercise Year: 2014/2016

Approved Project Duration: 36 months

Project Fund: HK$ 1,200,000

Coordinator: Dr. Defang Li (Ph.D.) and Mr. Chao Liang (M.S.)

2.

Zhang G   (Corresponding Author), Guo    B, Wu H, Tang T,   Zhang BT, Zheng L, He Y, Yang  Z, Pan X, Chow H,  To K, Li Y, Li   D,Wang X, Wang  Y, Lee K, Hou Z, Dong N, Li G, Leung K,   Hung    L, He F, Zhang L (Corresponding Author), Qin L  (Corresponding   Author). A delivery system targeting bone formation  surfaces  to   facilitate RNAi-based anabolic therapy. Nat  Med. 2012     Jan 29;18(2):307-14.

2.

Zhang Z, Lu     C (Co-first   author), Liu X, Su  J, Dai W, Yan S, Lu A, Zhang W.     Global and  Targeted Metabolomics Reveal that Bupleurotoxin, a    Toxic  Type of Polyacetylene,  Induces Cerebral Lesion by    Inhibiting GABA   receptor in Mice. J  Proteome Res.   2013 Dec 16.  [Epub  ahead of print]

3.

Shek Man Chim,   Jennifer Tickner, Siu  To Chow,  Vincent Kuek, Baosheng Guo, Ge Zhang, Vicki   Rosen, Wendy Erber, Jiake  Xu. Angiogenic factors in bone local    environment. Cytokin  Growth Factor Rev. 2013   Apr 20. doi:pii:    S1359-6101(13)00028-2.10.1016/j.cytogfr.   2013.03.008. [Epub ahead of   print]

4.

Huang C, Zheng   C, Li Y, Wang Y, Lu A, Yang L.  Systems pharmacology in   drug discovery and therapeutic insight for herbal  medicines. Brief   Bioinform. 2013 Jun 3. [Epub ahead  of   print]

5.

Chen SH, Wang   XL, Xie XH, Zheng LZ,   Yao D, Wang  DP, Leng Y, Zhang G    (Corresponding Author), Qin L (Corresponding    Author). Comparative study of osteogenic potential of a     composite  scaffold incorporating either endogenous bone    morphogenetic protein-2 or  exogenous phytomolecule icaritin: an   in  vitro efficacy  study. Acta Biomater. 2012 Aug;8(8):3128-37

6.

Xie XH, Wang   XL, He YX, Liu Z, Sheng H, Zhang G  (Corresponding Author), Qin L   (Corresponding Author). Promotion of bone  repair by implantation of     cryopreserved bone marrow-derived  mononuclear cells in a rabbit   model of  steroid-associated  osteonecrosis. Arthritis   Rheum. 2012  May; 64(5):1562-71

7.

Tan Y, Li J,   Liu X, Ko J, He X, Lu C,   Liu Z,  Zhao H, Xiao C, Niu X, Zha Q, Yu   Z,  Zhang W, Lu A    (Corresponding Author). Deciphering   the differential toxic responses of Radix  aconiti lateralis praeparata   in healthy and hydrocortisone-pretreated rats  based on serum metabolic   profiles. J Proteome Res. 2013 Jan 4;  2(1):513-24.

8.

Zhang C, Jiang   M, Lu A  (Corresponding Author).   Considerations  of traditional Chinese medicine as adjunct therapy in   the management of  ulcerative colitis. Clin   Rev Allergy   Immunol. 2013  Jun;44(3):274-83.

9.

Zhao L,   Nicholson JK, Lu A, Wang Z, Tang   H, Holmes E,    Shen J, Zhang X, Li JV, Lindon JC. Targeting the human    genome-microbiome axis for drug discovery: inspirations from global     systems  biology and traditional Chinese medicine. J   Proteome   Res.2012 Jul  6;11(7):3509-19.

10.

Zhang G, Sheng H, He   YX, Xie  XH, Wang   YX, Lee KM, Yeung KW, Li ZR, He  W,   Griffith JF, Leung KS, Qin L. Continuous occurrence of both    insufficient neovascularization and   elevated vascular   permeability in rabbit  proximal femur during  inadequate    repair of steroid-associated osteonecrotic  lesions. Arthritis     Rheum. 2009  Oct; 60(10):2966-77.

11.

Zhang G, Qin L, Shi   Y. Epimedium-derived  phytoestrogen flavonoids exert beneficial effect   on preventing bone loss in late postmenopausal women: a 24-month    randomized,  double-blind  and placebo-controlled trial. J   Bone  Miner Res. 2007 Jul;22(7):1072-9.

2.

Protein Kinase   C Inhibitor, GF109203X Attenuates  Osteoclastogenesis, Bone Resorption   and RANKL-induced NF-κB and NFAT  activity. Yao J, Li J, Zhou L, Cheng   J, Chim SM, Zhang G, Quinn JM, Tickner  J, Zhao J, Xu J.J Cell   Physiol. 2014 Nov 3. doi:  10.1002/jcp.24858.

3.

Sheng H, Rui    XF, Sheng CJ, Li WJ, Cheng XY, Jhummon NP, Yu YC, Qu S, Zhang G, Qin L. A    novel semisynthetic molecule icaritin stimulates osteogenic   differentiation  and inhibits adipogenesis of mesenchymal stem cells. Int   J Med Sci. 2013;10:  782-9

4.

Shanthanagouda    AH, Guo BS, Ye RR, Liang C,  Chiang WL, Singaram G, Cheung KM, Zhang  G   (Corresponding author), Au WT  (Corresponding author).    Japanese Medaka: A  Non-Mammalian Vertebrate Model for Studying   Sex and  Age-Related Bone Metabolism in vivo. PLoS One.    2014  Jan 5;9(2):e88165.

5.

Zheng LZ, Liu    Z, Lei M, Peng J, He YX, Xie XH, Man CW, Huang L, Wang XL,  Fong   DT,  Xiao DM, Wang DP, Chen Y, Feng JQ, Liu Y, Zhang G  (Corresponding    author), Qin L  (Corresponding author).   Steroid-associated hip joint collapse in bipedal  emus.PLoS One.    2013 Oct 21;8(10):e76797.

6.

Liu B, Zhang     H, Li J,  Lu C,  Chen G, Zhang G, Lu A, He X.  Triptolide     downregulates   Treg cells and the level of IL-10,  TGF-β,    and VEGF in   melanoma-bearing  mice. Planta Med.   2013   Oct;79(15):1401-7.

7.

Jiang M, Chen     T, Feng  H,  Zhang Y, Li  L, Zhao A, Niu X, Liang F,    Wang M, Zhan J, Lu C,  He X, Xiao  L,  Jia W, Lu A. Serum    metabolic  signatures of    four types of human    arthritis. J Proteome Res. 2013 Aug 2;12(8):3769-79. doi:   10.1021/pr400415a.

8.

Guo B, Zhang     B, Zheng  L, Tang  T, Liu  J, Wu H, Yang Z, Peng S, He    X, Zhang H, Yue KK,  He F, Zhang L, Qin L, Bian Z, Tan W, Liang Z, Lu A, Zhang G. Therapeutic     RNA   interference  targeting CKIP-1 with a cross-species    sequence to   stimulate bone   formation. Bone.    2013;59:76-88.

9.

Peng S, Zhang G   (Co-first author), Zhang BT,  Guo B, He Y, Bakker AJ, Pan  X,   Zhen W, Hung  L, Qin L, Leung WN.  The  Beneficial Effect of    Icaritin on Osteoporotic  Bone is  Dependent on the    Treatment  Initiation Timing in Adult  Ovariectomized Rats. Bone.   2013 Feb  25. [Epub ahead of  print]    

10.

Yang Z, Lu A,    Wong BC, Chen X,  Bian Z, Zhao  Z, Huang W, Zhang   G, Chen H, Xu  M. Effect  of Liposomes on the Absorption of   Water-Soluble Active  Pharmaceutical  Ingredients Via Oral   Administration. Curr Pharm Des. 2013 Apr 23.   [Epub ahead   of print]

11.

Wang XL, Xie    XH, Zhang G, Chen SH, Yao  D, He K, Wang XH,    Yao XS,  Leng Y, Fung KP, Leung KS, Qin L. Exogenous     phytoestrogenic molecule   icaritin incorporated into a porous    scaffold  for enhancing bone defect   repair. J   Orthop Res. 2013   Jan;31(1):164-7.

12.

Xu Q, Bauer R,    Hendry BM, Fan  TP, Zhao Z,  Duez P,  Simmonds MS, Witt   CM, Lu A, Robinson N,   Guo DA, Hylands PJ.   The quest for modernisation of traditional Chinese   medicine. BMC     Complement Altern Med. 2013 Jun 13;13:132.

13.

Liang F, Li L,    Wang M, Niu X,  Zhan J, He X,  Yu C, Jiang M, Lu A     (Corresponding Author). Molecular    network and   chemical fragment-based  characteristics of medicinal    herbs   with cold and hot  properties from Chinese   medicine. J     Ethnopharmacol. 2013 May 20.

14.

Wang LY,    Chan  KW,  Yuwen Y,  Shi   NN,  Han  XJ,     Lu A   (Corresponding Author).  Expert     consensus on  the treatment  of   hypertension      with  chinese  patent medicines. Evid  Based    Complement   Alternat  Med. 2013;2013:510146.    

15.

Dai  J,    Fang J, Sun S, Chen  Q, Cao H,  Zheng N,  Zhang Y, Lu A. ZHENG-Omics   Application in   ZHENG Classification and Treatment: Chinese   Personalized  Medicine. Evid  Based Complement Alternat    Med.   2013;2013:235969.

16.

Yang   Z, Lu A, Wong     BC, Chen  X, Bian    Z, Zhao  Z, Huang  W, Zhang     G, Chen  H, Xu    M. Effect of Liposomes on the      Absorption of Water-Soluble  Active  Pharmaceutical   Ingredients Via Oral     Administration. Curr Pharm    Des. 2013 Apr 23.    [Epub ahead of print]

17.

Liu C, Zhang    Y, Kong X, Zhu L,  Pang J, Xu  Y, Chen W, Zhan H, Lu A, Lin N.     Triptolide  Prevents Bone  Destruction in the   Collagen-Induced Arthritis  Model   of  Rheumatoid    Arthritis by Targeting RANKL/RANK/OPG Signal     Pathway. Evid   Based Complement Alternat Med.     2013;2013:626038. doi:   10.1155/2013/626038.

18.

Lu C, Liu X,    Ding X, Chen X, Fan  H, Liu Y,   Xie N, Tan Y,  Ko J,   Zhang W, Lu A   (Corresponding Author). A   Metabolomics Profiling Study in   Hand-Foot-and-Mouth Disease and    Modulated Pathways of  Clinical Intervention Using Liquid    Chromatography/Quadrupole Time-of-Flight Mass Spectrometry. Evid   Based  Complement   Alternat Med. 2013;   2013:647452.

19.

Zha Q, Lin S,    Zhang C,   Chang C, Xue H, Lu  C,  Jiang M, Liu Y, Xiao   Z, Liu W,  Shang  Y, Chen J, Wen  M, Lu A   (Corresponding Author). Xiaoqinglong    granules as    add-on  therapy for asthma: latent class analysis of     symptom predictors of   response. Evid Based  Complement     Alternat Med. 2013;2013:759476.  doi:     10.1155/2013/759476.

20.

Li X, Zhang C,    Shi Q, Yang T,  Zhu Q, Tian  Y, Lu C,  Zhang Z, Jiang Z,   Zhou H, Wen X,  Yang H,  Ding X,  Liang L, Liu Y, Wang Y,Lu A   (Corresponding Author). Improving   the efficacy of     conventional therapy by adding and rographolide  sulfonate   in the   treatment of severe hand, foot, and mouth disease: a   randomized    controlled trial. Evid Based  Complement Alternat     Med.2013;2013:316250.     doi:10.1155/2013/316250.

21.

Xie XH, Wang    XL, Zhang  G, He YX, Leng    Y, Tang TT,   Pan X,  Qin L. Biofabrication of a PLGA-TCP-based   porous   bioactive  bone substitute with sustained release of  icaritin. J    Tissue Eng   Regen Med.  2012  Dec 18.

22.

Baosheng Guo,    Songlin Peng, Chao  Liang,  Xiaojuan He,  Cheng    Xiao, Cheng Lu, Miao  Jiang,   Hongyan Zhao, Aiping Lu   (Corresponding Author), Ge Zhang    (Corresponding   Author).  Recent  developments in bone     anabolic therapy for osteoporosis.Expert   Review of    Endocrinology   & Metabolism. 2012 Nov;7(6): 677-685

23.

Zhu GY,     Wong BC,  Lu A,  Bian  ZX, Zhang G,  Chen  HB,  Wong YF,      Fong WF,  Yang Z.  Alkylphenols  from the roots   of   Ardisia  brevicaulis induce G1 arrest and   apoptosis   through  endoplasmic   reticulum stress pathway in human    non-small-cell lung cancer  cells. Chem Pharm  Bull    (Tokyo).   2012;60(8):1029-36.

24.

Wei F,     Moore DC,  Li Y, Zhang  G,  Wei X,    Lee JK,    Wei L.  Attenuation of  osteoarthritis   via    blockade of the SDF-1/CXCR4 signaling pathway. Arthritis     Res   Ther. 2012 Jul   31;14(4):R177

25.

Zhu HM     (Co-first author), Qin L   (Co-first   author), Garnero P     (Co-first author), Genant HK   (Co-first   author), Zhang    G(Co-first author), Dai K,    Yao X,  Gu G,   Hao Y,  Li Z,  Zhao Y,  Li W, Yang  J,   Zhao X,    Shi D,  Fuerst T,   Lu Y, Li H, Zhang X,    Li C,   Zhao J, Wu Q, Zhao SJ. The first   multicenter and   randomized   clinical trial of herbal Fufang for treatment of   postmenopausal   osteoporosis.Osteoporos  Int. 2012       Apr;23(4):1317-27.

26.

He YX,     Liu Z,  Pan XH,   Tang T,   Guo BS,  Zheng LZ,   Xie   XH,  Wang XL,   Lee KM,   Li G, Cao YP,  Wei L,     Chen Y, Yang ZJ,  Hung LK,   Qin L,  Zhang G    (Corresponding Author).     Deletion of estrogen   receptor  beta accelerates early stage of  bone  healing in    a mouse osteotomy  model. Osteoporos Int.  2012     Jan;23(1):377-89.

27.

Li J, Lu C,    Jiang M, Niu X, Guo  H, Li L,  Bian Z,  Lin N, Lu A     (Corresponding   Author). Traditional  chinese   medicine-based  network pharmacology could lead to new multicompound      drug   discovery. Evid Based Complement Alternat   Med.  2012;2012:149762.

28.

Yang  H,    Yang J, Wen Z, Zha  Q, Nie G,   Huang X, Zhang  C, Lu A     (Corresponding Author), Jiang M,    Wang X. Effect of     combining therapy with traditional chinese    medicine-based    psychotherapy and  herbal medicines in women  with    menopausal syndrome: a randomized controlled clinical trial. Evid     Based   Complement Alternat Med. 2012;   2012:354145.

29

Jiang M, Lu C,    Chen G, Xiao C,  Zha Q, Niu  X, Chen S, Lu A     (Corresponding Author).  Understanding the molecular   mechanism of interventions in  treating   rheumatoid    arthritis patients  with corresponding    traditional   chinese medicine patterns based on bioinformatics    approach. Evid   Based Complement Alternat Med. 2012;2012:129452.

30

Zhang  Z,    Niu X, Lu C,  Jiang M, Xiao  GG, Lu A     (Corresponding Author).  The   effect of curcumin on    human bronchial  epithelial cells exposed to  fine      particulate matter: a predictive  analysis. Molecules. 2012   Oct 22;17(10):12406-26.

31.

Shi  N,    Han X, Yu W, Wang  L, Lu A    (Corresponding   Author).   Adoption in China of Clinical  Practice     Guidelines for hypertension using Traditional Chinese Medical     approaches: a  literature  review based on clinical   studies. J    Altern Complement Med. 2013  Jan;19(1):1-8.

32.

Su  SB, Lu A,  Li S,     Jia W.  Evidence-Based  ZHENG: A Traditional Chinese   Medicine Syndrome. Evid Based Complement Alternat Med. 2012;2012:246538.

33.

Zhao  J,    Zha Q, Jiang M,  Cao H, Lu A    (Corresponding   Author). Expert consensus on the treatment  of rheumatoid    arthritis with Chinese patent  medicines. J Altern     Complement Med. 2013   Feb;19(2):111-8.

34.

Zhu  GY,    Wong BC, Lu A,  Bian    ZX, Zhang    G, Chen  HB, Wong YF, Fong WF, Yang Z.   Alkylphenols    from  the roots of  Ardisia brevicaulis  induce  G1   arrest and apoptosis through   endoplasmic   reticulum stress    pathway in human non-small-cell lung   cancer cells. Chem   Pharm  Bull (Tokyo). 2012;60(8):1029-36.

35.

Li X, He X,    Liu B, Xu  L,  Lu C, Zhao   H, Niu X, Chen S, Lu A     (Corresponding Author).     Maturation of murine bone   marrow-derived dendritic cells induced by    Radix    Glycyrrhizae  polysaccharide. Molecules.  2012    May 30;17(6):6557-68.

36.

Jiang M, Zhang    C, Zheng G, Guo  H, Li L,  Yang J, Lu  C,  Jia W, Lu A    (Corresponding Author).    Traditional chinese   medicine   zheng in the era of evidence-based   medicine: a    literature   analysis. Evid Based  Complement   Alternat Med.   2012;2012:409568. doi:  10.1155/2012/409568.

37.

Guo DA, Lu A, Liu L.     Modernization of    traditional Chinese medicine. J     Ethnopharmacol. 2012  Jun  1;141(2):547-8.

38.

Zhao  H,    Li J, He X, Lu C,  Xiao C, Niu  X, Zhao N, Ju D, Lu A      (Corresponding  Author). The  protective effect of yi   shen    juan bi  pill in arthritic  rats with   castration-induced kidney   deficiency. Evid    Based   Complement Alternat Med.2012;2012:102641.

39.

Lu  C,    Niu X, Xiao C, Chen  G, Zha Q,  Guo H, Jiang  M, Lu A     (Corresponding Author).     Network-based gene   expression biomarkers for cold and heat patterns of     rheumatoid   arthritis in  traditional chinese  medicine. Evid Based   Complement Alternat Med. 2012;2012:203043.

40.

Gu  Y, Lu    C, Zha Q, Kong H,  Lu  X, Lu A    (Corresponding   Author), Xu G.  Plasma metabonomics study  of    rheumatoid arthritis and its Chinese   medicine  subtypes by   using   liquid chromatography and gas   chromatography coupled with     mass spectrometry.Mol Biosyst. 2012   Apr;8(5):1535-43.

41.

He  X,    Shu J, Xu L, Lu C, Lu A     (Corresponding Author).     Inhibitory effect of Astragalus    polysaccharides on   lipopolysaccharide-induced  TNF-a and IL-1β    production in   THP-1  cells. Molecules. 2012  Mar   12;17(3):3155-64.

42.

Chan K, Shaw    D, Simmonds MS,  Leon CJ, Xu   Q, Lu A, Sutherland     I, Ignatova S,    Zhu YP, Verpoorte R, Williamson EM, Duez   P.  Good  practice in   reviewing and  publishing studies   on  herbal medicine, with   special emphasis on traditional     Chinese medicine and  Chinese materia   medica. J    Ethnopharmacol. 2012   Apr     10;140(3):469-75.

43.

Jiang M, Lu C,    Zhang C, Yang J,   Tan   Y, Lu A  (Corresponding Author), Chan K.       Syndrome  differentiation in modern research of   traditional  Chinese    medicine. J    Ethnopharmacol. 2012 Apr 10;   140(3):634-42.

44.

Wang X, Zhen    L, Zhang G,  Wong  MS,  Qin L,     Yao  X.  Osteogenic effects of   flavonoid aglycones    from an osteoprotective fraction of   Drynaria fortunei--an    in  vitro  efficacy study. Phytomedicine.    2011 Jul   15;18(10):868-72.

45.

He YX, Zhang G     (Corresponding Author),  Pan  XH,  Liu Z,    Zheng   LZ,  Chan CW,  Lee KM,   Cao YP,  Li   G, Wei L, Hung  LK, Leung KS, Qin L(Corresponding    Author).   Impaired  bone healing  pattern in mice with  ovariectomy-induced   osteoporosis: A drill-hole  defect model. Bone. 2011 Jun       1;48(6):1388-400

46.

Xie XH,     Wang XL, Zhang G, Liu Z,    Yao D,  Hung   LK,   Hung VW,  Qin L.  Impaired bone   healing in    rabbits with steroid-induced osteonecrosis. J  Bone    Joint Surg Br. 2011   Apr;93(4):558-65.

47.

Tang T     (Co-first author), Zhang G   (Co-first  author), Lau CP,     Zheng LZ,  Xie XH,   Wang XL,  Wang XH,  He K,   Patrick Y,   Qin L, Kumta SM.  Effect  of  water-soluble   P-chitosan and  S-chitosan on human  primary   osteoblasts    and giant cell tumor of  bone stromal  cells. Biomed    Mater. 2011  Feb;6(1):015004

48.

Zheng  G,    Jiang M, He X,  Zhao J, Guo  H, Chen G,  Zha Q, Lu A     (Corresponding Author). Discrete     derivative: a   data  slicing algorithm for exploration of  sharing     biological  networks  between rheumatoid arthritis  and   coronary heart disease.BioData   Min. 2011 Jun  23;4:18.

49.

Jiang  M,    Xiao C, Chen G,  Lu C, Zha Q,  Yan X, Kong  W, Xu S, Ju   D, Xu P, Zou  Y, Lu A    (Corresponding Author).     Correlation between cold  and hot pattern  in traditional Chinese     medicine and  gene  expression  profiles in rheumatoid    arthritis.Front Med.  2011  Jun;5(2):219-28.

50.

Liu  Z,    Liu Y, Wang C, Guo  N, Song Z,  Wang C, Xia  L, Lu A     (Corresponding Author).     Comparative analyses of   chromatographic fingerprints of the roots of     Polygonum   multiflorum  Thunb. and their processed products  using   RRLC/DAD/ESI-MS(n). Planta  Med. 2011    Nov;77(16):1855-60.

51.

Xiao  C,    Li J, Dong X, He  X, Niu X,  Liu C, Zhong  G, Bauer R,   Yang D, Lu A    (Corresponding  Author).      Anti-oxidative and TNF-α  suppressive activities of puerarin   derivative   (4AC)  in RAW264.7   cells and collagen-induced   arthritic  rats. Eur J   Pharmacol. 2011   Sep;666(1-3):242-50.

52.

Jiang  M,    Zha Q, Lu C, He  Y, Lu A    (Corresponding   Author).    Association between tongue     appearance in Traditional Chinese Medicine  and effective response    in  treatment of rheumatoid  arthritis. Complement     Ther Med. 2011   Jun;19(3):115-21.

53.

Zhang  C,    Jiang M, Lu A     (Corresponding Author). traditional     Chinese medicine    versus Western combination therapy in   the treatment of rheumatoid   arthritis:  two-stage study protocol   for a  randomized  controlled   trial. Trials.   2011 Jun   4;12:137.

54.

Jiang  M,    Zhang C, Cao H,  Chan  K, Lu A    (Corresponding   Author). The role    of Chinese medicine in     the treatment of chronic diseases in   China. P  lanta    Med. 2011   Jun;77(9):873-81.

55.

Li J, Lu Y,    Xiao C, Lu C, Niu X,  He X, Zhao   H,  Tan Y, Lu A     (Corresponding Author).     Comparison of toxic   reaction of Tripterygium wilfordii multiglycoside    in    normal and adjuvant  arthritic rats.  Ethnopharmacol.  2011    May  17;135(2):270-7.

56.

Liu Z, Liu Y,    Chao Z, Song Z,  Wang C, Lu A   (Corresponding Author).  In     vitro antioxidant  activities of maillard reaction products    produced in  the   steaming process of Polygonum multiflorum     root. Nat  Prod  Commun. 2011 Jan;6(1):55-8.

57.

Song XS, Zhou    XZ, Zhang G, Dong QR,    Qin L.    Low-dose  X-ray irradiation  promotes fracture   healing   through up-regulation of vascular endothelial  growth  factor. Med    Hypotheses. 2010   Dec;75(6):522-4.

58.

Xie XH,     Wang XL, Zhang G, He YX,    Wang XH,  Liu   Z,   He K, Peng J,  Leng Y,  Qin L.    Structural   and  degradation characteristics of an innovative   porous PLGA/TCP     scaffold incorporated  with bioactive  molecular    icaritin. Biomed Mater. 2010 Oct;5(5):054109.

59.

Wang XL, Wang    NL,  Gao H, Zhang G, Qin L,    Wong MS,    Yao XS.   Phenylpropanoid and flavonoids   from   osteoprotective fraction of  Drynaria fortunei. Nat Prod Res.    2010    Aug;24(13):1206-13.

60.

Zhang P, Qin    L, Zhang    G. The    potential   application of nicotinic   acetylcholine receptor agonists for     the  treatment of  rheumatoid arthritis.  Inflamm    Res. 2010    Jun;59(6):415-7.

61.

Qin L,     Wang L,  Wong MW,   Wen C,   Wang G,  Zhang G,  Chan    KM,  Cheung   WH,  Leung KS.  Osteogenesis Induced   by   Extracorporeal   Shockwave in Treatment of Delayed    Osteotendinous   Junction   Healing. J Orthop Res.   2010 Jan;28(1):70-6.

62.

Liang Z, Zhu    X, Yang X, Fu W, Lu A.     Assessment of a   traditional  acupuncture therapy for chronic neck  pain:   a   pilot randomised controlled study. Complement  Ther Med. 2011     Jan;19   Suppl 1:S26-32.

63.

Ma W, Bai W,    Lin C, Zhou P, Xia  L, Zhao C,   Hao Y,  Ma H, Liu X,   Wang J, Yuan H,  Xie Y, Lu A.    Effects of Sanyinjiao   (SP6)   with electroacupuncture on labour   pain in women    during  labour. Complement   Ther Med. 2011   Jan;19   Suppl 1:S13-8.

64.

Jiang M, Yang    J, Zhang C, Liu B,  Chan K,  Cao H, Lu A     (Corresponding Author). Clinical   studies with     traditional Chinese medicine in the past  decade and  future    research and  development. Planta   Med. 2010     Dec;76(17):2048-64.

65.

Zhao N, Zhang    W, Guo Y, Jia H,  Zha Q, Liu   Z, Xu  S, Lu A    (Corresponding   Author). Effects on neuroendocrinoimmune   network of  Lizhong Pill in the reserpine induced  rats  with   spleen  deficiency  in  traditional Chinese  medicine. J     Ethnopharmacol.  2011 Jan 27;133(2):454-9.

66.

Wang HH,    Wang YX, Griffith JF,  Sun  YL, Zhang G, Chan CW,      Qin L,  Ahuja  AT, Teng LS.  Pitfalls in   interpreting  rat  knee joint  magnetic resonance images and   their   histological   correlation. Acta  Radiol.   2009  Nov;50(9):1042-8

67.

Peng S     (Co-first author), Zhang G   (Co-first  author), He Y, Wang    X,  Leung P,    Leung K,  Qin L.     Epimedium-derived  flavonoids  promote  osteoblastogenesis and   suppress   adipogenesis in   bone marrow  stromal cells while   exerting an anabolic  effect   on osteoporotic  bone. Bone.   2009  Sep;45(3):534-44  

68.

Zhang G,  Wang    XL,  Sheng H,    Xie XH,  He YX,  Yao XS,    Li ZR,   Lee KM,   He  W, Leung KS,  Qin L.   Constitutional flavonoids  derived from  Epimedium dose-dependently   reduce   incidence of   steroid-associated osteonecrosis not via   direct  action by  themselves on  potential  cellular   targets. PLoS One.  2009  Jul  29;4(7):e6419.

69.

Sheng H, Zhang    G, Wang YX,  Yeung DK, Griffith  JF, Leung KS,   Qin L. Functional perfusion  MRI  predicts   later occurrence   of steroid-associated   osteonecrosis:  an  experimental    study in rabbits. J Orthop  Res.   2009    Jun;27(6):742-7.

70.

Wang HH,     Wang YX,  Sheng  H,  Zhang G, Qin L,   Ahuja AT,  Teng     LS.  Fossa trochanterica of the   proximal femur in rabbits:    an anatomic structure  for  potential misinterpretation    on magnetic   resonance images. Acta Radiol. 2009    Mar;50(2):212-6.  

71.

Zhang G, Qin L,     Sheng H,  Wang XL,    Wang YX,  Yeung DK,    Griffith  JF,  Yao XS,    Xie XH,  Li ZR,    Lee KM, Leung KS.   A novel   semisynthesized small    molecule icaritin reduces incidence  of      steroid-associated osteonecrosis  with inhibition of both      thrombosis and lipid-deposition in a dose-dependent  manner. Bone.     2009   Feb;44(2):345-56.

72.

Zhou XZ, Zhang G, Dong QR,      Chan CW,   Liu CF,  Qin L.  Low-dose   X-irradiation    promotes  mineralization of fracture callus   in a rat model. Arch    Orthop  Trauma  Surg.   2009 Jan;129(1):125-32.

73.

Qin L, Zhang G, Sheng H,     Wang XL, Wang YX,  Yeung KW, Griffith JF, Li ZR, Leung KS, Yao   XS.   Phytoestrogenic  compounds for prevention of   steroid-associated   osteonecrosis.  J   Musculoskelet   Neuronal Interact.  2008    Jan-Mar;8(1):18-21.

74.

Wang XL,     Wang NL,  Zhang  Y,  Gao  H,  Pang WY,    Wong  MS, Zhang G, Qin L, Yao  XS.  Effects    of eleven flavonoids  from the osteoprotective  fraction of    Drynaria  fortunei  (KUNZE) J. SM.  on    osteoblastic  proliferation using an   osteoblast-like cell   line.Chem   Pharm  Bull  (Tokyo).  2008   Jan;56(1):46-51.

75.

Zhang G,  Qin L,     Sheng H,    Yeung KW,  Yeung HY,  Cheung WH,     Griffith J,   Chan CW,   Lee KM,  Leung KS.   Epimedium-derived    phytoestrogen   exert beneficial effect on  preventing     steroid-associated  osteonecrosis  in rabbits with  inhibition    of both thrombosis  and  lipid-deposition. Bone.    2007   Mar;40(3):685-92.

76.

Hao YJ, Zhang G, Wang YS, Qin     L, Hung WY,  Leung K, Pei FX. Changes of microstructure and   mineralized  tissue in  the middle and late phase  of    osteoporotic  fracture   healing in rats. Bone.   2007  Oct;41(4):631-8.

77.

Qin L, Zhang G,  Sheng     H, Yeung KW,  Yeung HY,  Chan CW, Cheung WH, Griffith J,   Chiu KH,  Leung    KS. Multiple   bioimaging modalities   in evaluation of an    experimental osteonecrosis  induced    by a combination of    lipopolysaccharide and   methylprednisolone. Bone. 2006    Oct;39(4):863-71.

78.

Zhang G,  Qin L,     Hung WY,   Shi  YY,  Leung PC,  Yeung HY,    Leung KS.    Flavonoids  derived from herbal Epimedium   Brevicornum Maxim   prevent   OVX-induced osteoporosis in rats    independent of its   enhancement  in intestinal  calcium   absorption.Bone. 2006    Jun;38(6):818-25.

79.

Zhang G    (Corresponding   Author), Qin L,   Shi Y,  Leung K.     A   comparative study between axial  compression and lateral   fall  configuration  tested in a rat  proximal femur model. Clin     Biomech  (Bristol, Avon). 2005   Aug;20(7):729-35.

80.

Qin L, Zhang G, Hung WY, Shi     Y, Leung K,  Yeung HY, Leung P. Phytoestrogen-rich herb formula       "XLGB" prevents OVX-induced deterioration of   musculoskeletal     tissues at the hip in old rats. J Bone   Miner Metab. 2005;23. Suppl:55-61.