The Fifth Endocrine and Metabolic Forum of Shanghai Tenth People’s Hospital of Tongji University was held in Shanghai on October 30-31, 2015. The sponsor invited many famous domestic/foreign basic and clinical experts to attend and give a speech on hotspot issues including selective insulin resistance and hepatic fat deposition, the etiological mechanism of obesity and metabolic surgery therapy, basic and clinical research on bone osteoporosis and metabolic osteopathy, etc. Prof. Ge Zhang, he was invited to attend this meeting and give a speech entitled “Progress in the research on the targeting delivery system of small interfering RNA for anti-osteoporosis”.