The 2018 Natural Product symposium was successfully completed in Shanghai on April 13, 2018.This symposium focused on the critical issues in the discovery of new drugs from the natural products.Prof.Zhang Ge was invited to atted this symomsium and give a lecture entitled "From mechanistic understandings to precision medicine:Ligustrazine facilitates Leflunomide attenuating progressive bone erosion in rheumatoid arthritis with high serum C-reactive ptotein level".