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  • Research
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Associate Director, Technology Development Division; Associate Professor, Teaching and Research Division

Expert in Pharmacology of Chinese Medicine

zlyu@hkbu.edu.hk

Dr. Yu received his undergraduate education at the Henan University of Traditional Chinese Medicine, and obtained his PhD degree in biochemistry from the Hong Kong University of Science and Technology. Before joining the Hong Kong Baptist University, Dr. Yu worked at the China Pharmaceutical University as a teaching assistant, an assistant professor and an associate professor; at the Nagasaki University, Japan, as a visiting scholar; at the Hong Kong University of Science and Technology as a Croucher Foundation scholar and a postdoctoral research fellow; at the Xiamen University as a professor; and at the Macau University as an assistant professor. Dr. Yu is known for his research in herbal pharmacology, focusing on anticancer, anti-inflammatory and melanogenesis-regulating herbs, and in quality control of Chinese medicinal materials. He has published more than 130 peer-reviewed research papers.

Dr. Yu once served as an associate editor for the LiShizhen Medicine and Materia Medica Research and now serves on editorial boards of LiShizhen Medicine and Materia Medica ResearchCurrent Topics in Nutraceutical Research,Pharmaceutica Analytica ActaWorld Journal of Translational Medicine. He is currently a technology advisory panel member of the Hong Kong Incu-Tech/Incu-Bio Technology Business Incubation Programme.



Current research interests: 1) Pharmacology of Chinese medicines, focusing on the mechanisms of action of anticancer, anti-inflammation and melanogenesis-modulation herbs; 2) Unique processing of Chinese medicinal herbs, focusing on the mechanisms underlying the processing of Chinese medicines, standardization of adjuvant materials used for the processing of Chinese medicinal herbs, and quality control of decoction pieces.


Funded Projects

Project 1

Title: Study on the Processing Standards for Toxic Chinese Materia Medica

Principal Investigator: Dr. Zhiling Yu

Funding Body: Hong Kong Innovation and Technology Commission

Project ID: GHP/030/13

Exercise Year: 2014

Approved Project Duration: 24 months

Project Fund: HK$ 3,395,600 (including Interns)





Project 2

Title: Investigation of the role of c-Met/Gab1 signaling in the anti-metastatic action of quercetin in melanoma

Principal Investigator: Dr. Zhiling Yu

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG1/13-14/062

Exercise Year: 2014

Approved Project Duration: 12 months

Project Fund: HK$ 50,000





Project 3

Title: Defining the role of STAT3 signaling in the anti-melanoma effects of atractylenolide II

Principal Investigator: Dr. Zhiling Yu

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG2/13-14/016

Exercise Year: 2014

Approved Project Duration: 12 months

Project Fund: HK$ 135,000





Project 4

Title: Anti-obesity effect of Schisandrin B

Principal Investigator: Dr. Zhiling Yu

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG2/13-14/030

Exercise Year: 2013-2014

Approved Project Duration: 24 months

Project Fund: HK$ 127,500





Project 5

Title: Investigation of the Role of ROS in the Enhancement Effects of Tanshinones on TRAIL-induced Apoptosis in Melanoma Cells

Principal Investigator: Dr. Anfernee Kai-Wing Tse

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG1/13-14/002

Exercise Year: 2013

Approved Project Duration: 12 months

Project Fund: HK$ 50,000





Project 6

Title: Elucidating the Roles of Vitamin D Receptor on TRAIL Signaling in Melanoma

Principal Investigator: Dr. Anfernee Kai-Wing Tse

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG1/13-14/028

Exercise Year: 2013

Approved Project Duration: 12 months

Project Fund: HK$ 50,000





Project 7

Title: Mechanistic and functional studies of IKK inhibitors as sensitizing agents for anti-melanoma alkylating drugs

Principal Investigator: Dr. Anfernee Kai-Wing Tse

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG2/13-14/046

Exercise Year: 2013

Approved Project Duration: 12 months

Project Fund: HK$ 120,000





Project 8

Title: Anti-obesity effect of cinnamon

Principal Investigator: Dr. Hiu Yee Kwan

Funding Body: Research Grants Council, the General Research Funds

Project ID: HKBU 260313

Exercise Year: 2013-2014

Approved Project Duration: 24 months

Project Fund: HK$ 504,065



Project 9

Title: Standardization of the Vinegar for Processing Chinese Materia Medica

Principal Investigator: Dr. Zhiling Yu

Funding Body: Hong Kong Innovation and Technology Commission

Project ID: UIM/238

Exercise Year: 2013

Approved Project Duration: 24 months

Project Fund: HK$ 3,227,730 (including Interns)





Project 10

Title: Research and Laboratory Work-Hong Kong Chinese Materia Medica Standards (HKCMMS) Phase VIII Project

Principal Investigator: Dr. Zhiling Yu

Funding Body: Hong Kong Health Department

Project ID: DH/12-13/04-RDD VIII

Exercise Year: 2013

Approved Project Duration: 12 months

Project Fund: HK$ 2,142,220





Project 11

Title: Lipidomic-based study of the regulatory role of Schisandrin B on fatty acid production in a hepatic steatosis mouse mode

Principal Investigator: Dr. Hiu Yee Kwan

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG2/12-13/039

Exercise Year: 2012-2013

Approved Project Duration: 24 months

Project Fund: HK$ 120,000





Project 12

Title: Evaluation of the chronic toxicity of a commonly used Chinese medicinal herb Siegesbeckiae Herba

Principal Investigator: Dr. Zhiling Yu

Funding Body: Hong Kong Food and Health Bureau

Project ID: No. 11122521

Exercise Year: 2012

Approved Project Duration: 24 months

Project Fund: HK$ 850,000





Project 13

Title: Evaluation and Characterization of the Inflammatory Properties of Ribosome Inactivating Protein Momorcharin derived from Momordica charantia

Principal Investigator: Dr. Anfernee Kai-Wing Tse

Funding Body: Hong Kong Food and Health Bureau

Project ID: 11122441

Exercise Year: 2012

Approved Project Duration: 24 months

Project Fund: HK$ 836,000





Project 14

Title: 二花營實方的抗炎活性及其分子機制研究

Principal Investigator: Dr. Zhiling Yu

Funding Body: Science and Technology Innovation Commission of Shenzhen

Project ID: JCYJ20120829154222473

Exercise Year: 20142

Approved Project Duration: 24 months

Project Fund: RMB 200,000





Project 15

Title: Evaluation of the anti-melanoma action of sesquiterpenes isolated from a traditional Chinese medicinal herb Atractylodis Macrocephalae Rhizoma

Principal Investigator: Dr. Zhiling Yu

Funding Body: Hong Kong Research Grants Council

Project ID: HKBU 262512

Exercise Year: 2011-2012

Approved Project Duration: 24 months

Project Fund: HK$ 707,908





Project 16 

Title: R&D Laboratory for Testing of Chinese Medicines

Principal Investigator: Dr. Zhiling Yu

Funding Body: Hong Kong Jockey Club Charities Trust

Project ID:  S/N Ref: 2012/0081

Exercise Year: 2012

Approved Project Duration: 24 months

Project Fund: HK$ 2,000,000








1419915657567167.jpg

 

  Dr. Hiu Yee Kwan (Ph.D)


  Research Assistant Professor

  Physiology

  Email: hykwan@hkbu.edu.hk








1419915764352376.jpg

 

  Dr. Kai Wing Tse (Ph.D)


  Research Assistant Professor

  Biochemistry

  Email: anfernee@hkbu.edu.hk








1419915657474371.png

 


  Ms. Huihui Cao


  Ph.D student

  Biomedical Sciences

  Email: 11467290@life.hkbu.edu.hk









1419916716228220.png

 

  Mr. Brian Chi-yan Cheng


  Ph.D student

  Biomedical Sciences 

  Email: brichian@hotmail.com









1419915658389127.png


  Ms. Xiuqiong Fu


  M.Phil student

  Biomedical Sciences

  Email: 13480405@life.hkbu.edu.hk














1.

Chao XJ, Chen ZW, Liu AM, He XX, Wang SG, Wang YT, Liu PQ, Ramassamy C, Mak SH, Wei Cui, Kong AN, Yu ZL, Han YF, Pi RB. Effect of Tacrine-3-caffeic Acid, A Novel Multifunctional Anti-Alzheimer’s Dimer, Against Oxidative-Stress-Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO-1 Pathway. CNS Neurosci Ther. 2014; doi: 10.1111/cns.12286.


2.

Wang L, Lu AP, Yu ZL, Bian ZX, Kwok HH, Yue, YK, Zhou LM, Chen HB, Xu M, Yang ZJ. The Melanogenesis-inhibitory Effect and the Percutaneous Formulation of Ginsenoside Rb1. AAPS PharmSciTech. 2014 Jun 4.


3.

Pan SY#, Litscher G#, Gao SH#, Zhou SF#, Yu ZL#, Chen HQ, Zhang SF, Tang MK, Sun JN, Ko KM. Historical perspective of traditional indigenous medical practices: The current renaissance and conservation of herbal resources. Evid Based Complement Alternat Med. 2014;2014:525340. [# co-first authors]


4.

Wang XY#, Yu ZL#, Pan SY, Zhang Y, Sun N, Zhu PL, Zhou SF, Ko KM. Supplementation with the extract of Schisandrae Fructus pulp, seed or their combination influences the metabolism of lipids and glucose in mice fed with normal and hypercholesterolemic diet. Evid Based Complement Alternat Med. 2014;2014:472638. [#co-first authors]


5.

Sun N, Pan SY*, Zhang Y, Wang XY, Zhu PL, Chu ZS, Yu ZL*, Zhou SF, Ko KM. Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol bile salt diet. Lipids Health Dis. 2014; 13:46.


6.

Wang H, Ye Y, Yu ZL*. Proteomic and functional analyses demonstrate the involvement of oxidative stress in the anticancer activities of oridonin in HepG2 cells. Oncol Rep. 2014;31:2165-72.


7.

Cheng BCY, Ma XQ, Kwan HY, Tse KW, Cao HH, Su T, Shu X, Wu ZZ, Yu ZL*. A herbal formula consisting of Rosae Multiflorae Fructus and Lonicerae Japonicae Flos inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. J Ethnopharmacol. 2014;153:922-7.


8.

Kwan HY*, Chao XJ, Su T, Fu XQ, Tse AK, Fong WF, Yu ZL*. The anti-cancer and anti-obesity effects of Mediterranean diet. Crit Rev Food Sci Nutr. Accepted.


9.

Pan SY, Gao SH, Zhou SF, Dong HG, Tang MK, Yu ZL, Ko KM. New perspectives on dietary-derived treatments and food safety ― Antinomy in a new era. Crit Rev Food Sci Nutr. 2013 Aug 2. [Epub ahead of print]


10.

Cao HH, Tse AK, Kwan HY, Yu H, Cheng CY, Su T, Fong WF, Yu ZL*. Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014;87:424-34.


11.

Yi T, Zhu L, Tang YN, Zhang JY, Liang ZT, Xu J, Zhao ZZ, Yu ZL, Bian ZX, Yang ZJ, Chen HB. An integrated strategy based on UPLC-DAD-QTOF-MS for metabolism and pharmacokinetic studies of herbal medicines: Tibetan "Snow Lotus" herb (Saussurea laniceps), a case study. J Ethnopharmacol. 2014;153:701-13.


12.

Tse AW, Cao HH, Cheng CY, Kwan HY, Yu H, Fong WF, Yu ZL*. Indomethacin Sensitizes TRAIL-Resistant Melanoma cells to TRAIL-induced Apoptosis through ROS-mediated Up-regulation of Death Receptor 5 and Down-regulation of Survivin. J Invest Dermatol. 2014;134:1397-407.


13.

韩钦芮,符秀琼,禹志领,孙学刚. 肿瘤微环境的脾虚本质探讨. 中医杂志 2014; 55:292-8.


14.

Li S, Chou G, Hseu Y, Yang H, Kwan HY, Yu ZL*. Isolation of anticancer constituents from flos genkwa (Daphne genkwa Sieb.et Zucc.) through bioassay-guided procedures. Chem Cent J. 2013;7:159.


15.

Ma XQ, Man Leung AK, Chan CL, Su T, Li WD, Li SM, Fun Fong DW, Yu ZL*. UHPLC UHD Q-TOF MS/MS analysis of the impact of sulfur fumigation on the chemical profile of Codonopsis Radix (Dangshen). Analyst. 2013;139:505-16.


16.

Xiao T, Zhang Y, Wang Y, Xu Y, Yu ZL, Shen X. Activation of an apoptotic signal transduction pathway involved in the upregulation of calpain and apoptosis-inducing factor in aldosterone-induced primary cultured cardiomyocytes. Food Chem Toxicol. 2013;53:364-70.


17.

Ma DL, Zhong HJ, Fu WC, Chan DS, Kwan HY, Fong WF, Chung LH, Wong CY, Leung CH. Phosphorescent imaging of living cells using a cyclometalated iridium (III) complex. PLoS One. 2013; 8(2):e55751.


18.

Leung KH, Lu L, Wang M, Mak TY, Chan DS, Tang FK, Leung CH, Kwan HY, Yu ZL, Ma DL. A label-free luminescent switch-on assay for ATP using a G-quadruplex-selective iridium(III) complex. PLoS One. 2013;8:e77021.


19.

Tse AK, Chow KY, Cao HH, Cheng CY, Kwan HY, Yu H, Zhu GY, Wu YC, Fong WF, Yu ZL*. The Herbal Compound Cryptotanshinone Restores Sensitivity in Cancer Cells that are Resistant to the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. J Biol Chem. 2013;288:29923-33.


20.

Pan SY, Jia ZH, Zhang Y, Yu Q, Wang XY, Sun N, Zhu PL, Yu ZL, Ko KM. A novel mouse model of combined hyperlipidemia associated with steatosis and liver injury bya single-dose intragastric administration of schisandrin B/cholesterol/bile salts mixture. J Pharmacol Sci. 2013;123:110-9.


21.

Kwan HY, Fong WF, Yang ZJ, Yu ZL*, Hsiao WL*. Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells. Eur J Nutr. 2013;52:1621-30.

22.

Wu JY, Yu ZL, Fong WF, Shi YQ. Chemotherapeutic activities of Carthami Flos and its reversal effect on multidrug resistance in cancer cells. Afr J Tradit Complement Altern Med. 2013;10:36-40.


23.

Fernandes NV, Yeganehjoo H, Katuru R, Debose-Boyd RA, Morris LL, Michon R, Yu ZL, Mo H. Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase. Exp Biol Med (Maywood). 2013;238:1265-74.


24.

Pan SY, Zhou SF, Gao SH, Yu ZL, Zhang SF, Tang MK, Sun JN, Ma DL, Han YF, Fong WF, Ko KM. New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics. Evid Based Complement Alternat Med. 2013;2013:627375.


25.

Kwan HY, Hu YM, Chan CL, Cao HH, Cheng CY, Pan SY, Tse KW, Wu YC, Yu ZL*, Fong WF*. Lipidomics identification of metabolic biomarkers in chemically induced hypertriglyceridemic mice. J Proteome Res. 2013;12:1387-98.


26.

Jones S, Fernandes NV, Yeganehjoo H, Katuru R, Qu H, Yu ZL, Mo H. β-ionone induces cell cycle arrest and apoptosis in human prostate tumor cells. Nutr Cancer. 2013;65:600-10.


27.

Tan Y, Li J, Liu X, Ko J, He X, Lu C, Liu Z, Zhao H, Xiao C, Niu X, Zha Q, Yu ZL, Zhang W, Lu A. Deciphering the Differential Toxic Responses of Radix aconiti lateralis praeparata in Healthy and Hydrocortisone-Pretreated Rats Based on Serum Metabolic Profiles. J Proteome Res. 2013;12:513-24.

28.

Kwan HY, Yang Z, Fong WF, Hu YM, Yu ZL*, Hsiao WL*. The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. J Gastroenterol. 2013;48:182-92.


29.

梁思敏, 马晓青, 禹志领*. 中药材硫磺熏蒸概况. 香港中医杂志 2013; 8:15-17.


30.

Yu ZL*. Mushroom and Health. Curr Top Nutraceutical Res. 2012; 10:V-VI.


31.

Huo L, Wu R, Yu ZL, Zhai Y, Yang X, Chan TC, Yeung JT, Kan J, Liang C. The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Cell Cycle. 2012;11: 1325-39.


32.

Pan SY, Yu Q, Zhang Y, Wang XY, Sun N, Yu ZL, Ko KM. Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity. Lipids Health Dis. 2012;11:120.


33.

Xu L, Chan CO, Lau CC, Yu ZL, Mok DK, Chen S. Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC-DAD. Phytochem Anal. 2012; 23:110-6.


34.

Pan SY, Gao SH, Zhou SF, Tang MK, Yu ZL, Ko KM. New perspectives on complementary and alternative medicine: an overview and alternative therapy. Altern Ther Health Med. 2012;18:20-36.


35.

Tsang TF, Ye Y, Tai WC, Chou GX, Leung AK, Yu ZL, Hsiao WL. Inhibition of the p38 and PKA signaling pathways is associated with the anti-melanogenic activity of Qian-wang-hong-bai-san, a Chinese herbal formula, in B16 cells. J Ethnopharmacol. 2012;141:622-8.


36.

Yi T, Lo H, Zhao Z, Yu ZL, Yang Z, Chen H. Comparison of the chemical composition and pharmacological effects of the aqueous and ethanolic extracts from a Tibetan "Snow Lotus" (Saussurea laniceps) herb. Molecules. 2012;17:7183-94.


37.

王辉, 叶燕,禹志领*.冬凌草甲素对HepG2细胞内质网应激蛋白IRE-1、PERK和CHOP的作用研究. 中药新药与临床药理 2012; 23:263-6.


38.

胡耀昌,方宏勋,禹志领,史亦谦.益母草逆转口腔癌细胞多药耐药作用. 时珍国医国药 2012; 23:2900-2.


39.

Cao HH, Yu ZL*. Quercetin Induces Apoptosis, Suppresses Migration and Invasion in Human Melanoma Cells through Inhibiting the STAT3 Pathway. Siriraj Med J. 2012; 6(Suppl 2):101.


40.

Kasiappan R, Shen Z, Tse AK, Jinwal U, Tang J, Lungchukiet P, Sun Y, Kruk P, Nicosia SV, Zhang X, Bai W. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. J Biol Chem. 2012 Nov 30;287(49):41297-309.


41.

Tse AK#, Yang Y#, Li P, Ma Q, Xiang S, Nicosia SV, Seto E, Zhang X, Bai W. Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 2011 May 12;30(19):2207-18. (# Equally contributed).


42.

Guo D, Xu L, Cao X, Guo Y, Ye Y, Chan CO, Mok DK, Yu ZL*, Chen S*. Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips. J Ethnopharmacol. 2011;138:717-22.


43.

Ye Y, Wang H, Chu JH, Chou GX, Fong WF, Yu ZL*. Atractylenolide II induces G1 cell-cycle arrest and apoptosis in B16 melanoma cells. J Ethnopharmacol. 2011; 136:279-82.


44.

Chu JH, Wang H, Ye Y, Chan PK, Pan SY, Fong WF, Yu ZL*. Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells. World J Gastroenterol. 2011; 17:2379-88.


45.

Pan SY, Dong H, Guo BF, Zhang Y, Yu ZL, Fong WF, Han YF, Ko KM. Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate. Naunyn Schmiedebergs Arch Pharmacol. 2011;383:585-91.


46.

Pan SY*, Guo BF, Zhang Y, Yu Q, Yu ZL*, Dong H, Ye Y, Han YF, Ko KM. Tacrine treatment at high dose suppresses the recognition memory in juvenile and adult mice with attention to hepatotoxicity. Basic Clin Pharmacol Toxicol. 2011;108:421-7.


47.

Pan SY, Chen SB, Dong HG, Yu ZL, Dong JC, Long ZX, Fong WF, Han YF, Ko KM. New perspectives on chinese herbal medicine (zhong-yao) research and development. Evid Based Complement Alternat Med. 2011;2011:403709.


48.

Zhu GY, Li YW, Tse AK, Hau DK, Leung CH, Yu ZL, Fong WF. 20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells. Eur J Pharmacol. 2011; 668:88-98.


49.

Hu Y, Yu ZL, Yang ZJ, Zhu G, Fong W. Comprehensive chemical analysis of Venenum Bufonis by using liquid chromatography/electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2011;56:210-20.


50.

Ye Y, Wang H, Chu JH, Chou GX, Yu ZL*. Activation of p38 MAPK pathway contributes to the melanogenic property of apigenin in B16 cells. Exp Dermatol. 2011; 20:755-7.


51.

Hu YM, Yu ZL, Fong WF. Stereoselective Biotransformation of Timosaponin A-III by Saccharomyces cerevisiae. J Microbiol Biotechnol. 2011; 21:582-9.


52.

Wang H, Ye Y, Pan SY, Zhu GY, Li YW, Fong DW, Yu ZL*. Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells. Phytomedicine. 2011;18:163-9.


53.

Zhu GY, Li YW, Hau KP, Jiang ZH, Yu ZL, Fong WF. Protopanaxatriol-type ginsenosides from the root of Panax ginseng. J Agric Food Chem. 2011; 59:200-5.


54.

Zhu GY, Li YW, Hau KP, Jiang ZH, Yu ZL, Fong WF. Acylated protopanaxadiol-type ginsenosides from the root of Panax ginseng. Chem Biodivers. 2011;8:1853-63.


55.

Li YW, Zhu GY, Shen XL, Chu JH, Yu ZL, Fong WF. Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells. Cancer Chemother Pharmacol. 2011;68:1315-23.


56.

Li YW, Zhu GY, Shen XL, Chu JH, Yu ZL and Fong WF. Furanodienone inhibits cell proliferation and survival by suppressing ERα signaling in human breast cancer MCF-7 cells. J Cell Biochem. 2011;112:217-24.


57.

Yi T, Chen HB, Zhao ZZ, Yu ZL, Jiang ZH. Comparison of the chemical profiles and anti-platelet aggregation effects of two “Dragon’s Blood” drugs used in traditional Chinese medicine. J Ethnopharmacol. 2011;133:796-802.


58.

Fang HY, Guo DJ, Chen SB, Pan SY, Yu ZL*. Proteomic identification of differentially expressed proteins in curcumin-treated MCF-7 cells. Phytomedicine. 2011;18:697-703.


59.

Wang H, Ye Y, Chu JH, Zhu GY, Fong WF, Yu ZL*. Proteomic and functional analyses reveal the potential involvement of endoplasmic reticulum stress and {alpha}-CP1 in the anticancer activities of oridonin in HepG2 cells. Integr Cancer Ther. 2011;10:160-7.


60.

Ye Y, Chou GX*, Wang H, Chu JH, Fong WF, Yu ZL*. Effects of sesquiterpenes isolated from Largehead Atractylodes Rhizome on growth, migration and differentiation of B16 melanoma cells. Integr Cancer Ther. 2011; 10:92-100.


61.

王辉, 叶燕,黄树林,禹志领*. Hsp70.1在冬凌草甲素处理的肝癌细胞中的作用研究. 广东药学院学报 2011; 27:243-6.


62.

Shen B, Kwan HY, Ma X, Wong CO, Du J, Huang Y, Yao X. cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase (MEK)-ERK1/2 signaling pathway. J Biol Chem. 2011 Jun 3; 286(22):19439-45.


63.

Kwan HY, Cheng KT, Ma Y, Huang Y, Tang NL, Yu S, Yao X. CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells. J Vasc Res. 2010; 47(2):148-56.


64.

Ye Y, Chu JH, Wang H, Xu H, Chou GX, Leung AK, Fong WF, Yu ZL*. Involvement of p38 MAPK signaling pathway in the anti-melanogenic effect of San-bai-tang, a Chinese herbal formula, in B16 cells. J Ethnopharmacol. 2010;132:533-5.


65.

Ye Y, Chou GX*, Mu DD, Wang H, Chu JH, Leung AK, Fong WF, Yu ZL*. Screening of Chinese herbal medicines for antityrosinase activity in a cell free system and B16 cells. J Ethnopharmacol. 2010; 129:387-90.

66.

Ye Y, Chou GX*, Wang H, Chu JH, Yu ZL*. Flavonoids, apigenin and icariin exert potent melanogenic activities in murine B16 melanoma cells. Phytomedicine. 2010; 18:32-5.


67.

Wang H, Ye Y, Chui JH, Zhu GY, Li YW, Fong DW, Yu ZL*. Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells. Oncol Rep. 2010; 24:647-51.


68.

Wang H, Chan PK, Pan SY, Kwon KH, Ye Y, Chu JH, Fong WF, Tsui WM*, Yu ZL*. ERp57 is up-regulated in free fatty acids-induced steatotic L-02 cells and human nonalcoholic fatty livers. J Cell Biochem. 2010;110:1447-56.


69.

Tse AK, Zhu GY, Wan CK, Shen XL, Yu ZL, Fong WF. 1alpha,25-Dihydroxyvitamin D3 inhibits transcriptional potential of nuclear factor kappa B in breast cancer cells. Mol Immunol. 2010; 47:1728-38.


70.

Wan CK, Tse AK, Yu ZL, Zhu GY, Wang H, Fong DW. Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae Chinensis. Phytomedicine. 2010; 17:702-5.


71.

Yi T, Zhao ZZ, Yu ZL, Chen HB. Comparison of the anti-inflammatory and anti-nociceptive effects of three medicinal plants known as "Snow Lotus" herb in traditional Uighur and Tibetan medicines. J Ethnopharmacol. 2010; 128:405-11.


72.

Pan SY, Pan S, Yu ZL, Chen SB, Fong WF, Han YF, Ko KM. New perspectives on innovative drug discovery: an overview. J Pharm Pharm Sci. 2010; 13:450-471.


73.

Liu J, Hu XG, Yang Q, Yu ZL, Zhao ZZ, Yi T, Chen HB. Comparison of the immunoregulatory function of different constituents in Radix Astragali and Radix Hedysari.  J Biomed Biotechnol. 2010; 2010:479426.


74.

Wang H, Chan PK, Kwon KH, Tsui MS, Yu ZL*. ERp57 is overexpressed in an in vitro hepatosteatosis model and livers of patients with nonalcoholic fatty liver disease. Hepatol Int. 2010; 4:7.


75.

Liang ZT, Chen HB, Yu ZL, Zhao ZZ. Comparison of raw and processed Radix Polygoni Multiflori (Heshouwu) by high performance liquid chromatography and mass spectrometry. Chin Med. 2010; 5:29.


76.

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